Amides can undergo hydrolysis in acidic or alkaline solution. Acids and bases are as a reagent rather than by the use of excess catalyst. This reaction is ireversibel.Pada acid hydrolysis, protonation of the carbonyl oxygen of the carbonyl carbon increases the susceptibility to nucleophilic attack. Nucleophilic attack by water on the carbonyl carbon causes the tetrahedral intermediate compound I, which is in equilibrium with form rather than protons, tetrahedral intermediate II. Reprotonasi can occur either at the tetrahedral intermediates of oxygen to reform the I or the nitrogen to form a tetrahedral intermediate III. Protonation at nitrogen is preferred because the NH2 group is a stronger base than OH groups. Of the two kemungkinangugus go on tetrahedral intermediates III group (-OH and NH3), NH3 is a weak base, so removed, to form a carboxylic acid end sebagaiproduk. Because the reaction is carried out in acid solution, NH3 be protonated after expelled from the tetrahedral intermediates. This prevents the reverse reaction. The mechanism is as follows http://www.scribd.com/doc/83982374/Tutorial-Ko-II
Amides can undergo hydrolysis in acidic or alkaline solution. Acids and bases are as a reagent rather than by the use of excess catalyst. This reaction is ireversibel.Pada acid hydrolysis, protonation of the carbonyl oxygen of the carbonyl carbon increases the susceptibility to nucleophilic attack. Nucleophilic attack by water on the carbonyl carbon causes the tetrahedral intermediate compound I, which is in equilibrium with form rather than protons, tetrahedral intermediate II. Reprotonasi can occur either at the tetrahedral intermediates of oxygen to reform the I or the nitrogen to form a tetrahedral intermediate III. Protonation at nitrogen is preferred because the NH2 group is a stronger base than OH groups. Of the two kemungkinangugus go on tetrahedral intermediates III group (-OH and NH3), NH3 is a weak base, so removed, to form a carboxylic acid end sebagaiproduk. Because the reaction is carried out in acid solution, NH3 be protonated after expelled from the tetrahedral intermediates. This prevents the reverse reaction. The mechanism is as follows
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