Why can not hydrolyze amide without a catalyst?

 In the reaction without a catalyst, not the protonated amide. Therefore, the water, a very poor nucleophile, to attack neutral amides are much more susceptible to nucleophilic attack than the protonated amide. In addition, the group of the tetrahedral intermediate is not protonated in the reaction without a catalyst. Therefore, the-OH group is away from the tetrahedral intermediate-because-OH is a weak base of the amide-NH2 reform. An amide to react with alcohols under acidic conditions for the same reason will react with water under acidic

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